VEGFR-2-IN-40
Product Specifications
UNSPSC Description
VEGFR-2-IN-40 is a VEGFR-2 inhibitor. VEGFR-2-IN-40 boosts early and late apoptosis. VEGFR-2-IN-40 decreases the levels immunomodulatory proteins TNF-α and IL-6 while showing a four-fold rise in an apoptotic marker caspase-3[1].
Target Antigen
Caspase; Interleukin Related; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;Immunology/Inflammation;Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/vegfr-2-in-40.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(/C(C)=N/NC(C2=CC=CN=C2)=O)=C1)C3=CC=CC=C3
Molecular Weight
358.39
References & Citations
[1]Yousef RG, et al. New nicotinamide derivatives as potential anticancer agents targeting VEGFR-2: design, synthesis, in vitro, and in silico studies. J Biomol Struct Dyn. 2023 Dec 15:1-18.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157546/VEGFR-2-IN-40-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157546/
Clinical Information
No Development Reported
Curated Selection
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