VEGFR-2-IN-40

VEGFR-2-IN-40 is a VEGFR-2 inhibitor. VEGFR-2-IN-40 boosts early and late apoptosis. VEGFR-2-IN-40 decreases the levels immunomodulatory proteins TNF-α and IL-6 while showing a four-fold rise in an apoptotic marker caspase-3[1].

Product Specifications

UNSPSC

12352005

Target

Caspase; Interleukin Related; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/vegfr-2-in-40.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(/C(C)=N/NC(C2=CC=CN=C2)=O)=C1)C3=CC=CC=C3

Molecular Formula

C21H18N4O2

Molecular Weight

358.39

References & Citations

[1]Yousef RG, et al. New nicotinamide derivatives as potential anticancer agents targeting VEGFR-2: design, synthesis, in vitro, and in silico studies. J Biomol Struct Dyn. 2023 Dec 15:1-18.