CG428-NEG
CG428-NEG is a TRK degrader negative control. CG428 inhibits cell growth and reduce TPM3-TRKA levels[1].
Product Specifications
CAS Number
2714560-39-9
UNSPSC
12352005
Target
PROTACs; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cg428-neg.html
Purity
97.6
Solubility
10 mM in DMSO
Smiles
O=C1N(C(CC2)C(N(C)C2=O)=O)C(C3=C1C=CC=C3NCCOCCC(N4CCN(C5=NC(C6=CN=C7C=CC(N8[C@@H](C9=CC=CC(F)=C9)CCC8)=NN76)=CC=C5)CC4)=O)=O
Molecular Formula
C44H45FN10O6
Molecular Weight
828.89
References & Citations
[1]Chen L, et al. Discovery of First-In-Class Potent and Selective Tropomyosin Receptor Kinase Degraders. J Med Chem. 2020 Dec 10;63 (23) :14562-14575.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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