PDK4-IN-2
PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle[1].
Product Specifications
CAS Number
[1616752-12-5]
UNSPSC
12352005
Target
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pdk4-in-2.html
Solubility
10 mM in DMSO
Smiles
COC(C1=CC2=C(C(O)=C1)C(C=C(C2=O)C)=O)=O
Molecular Formula
C13H10O5
Molecular Weight
246.22
References & Citations
[1]Kenichi Aizawa, et al. A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction. Cells. 2023 Dec 30;13 (1) :87.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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