PDK4-IN-2
Product Specifications
UNSPSC Description
PDK4-IN-2 (compound 8) is a pyruvate dehydrogenase kinase 4 (PDK4) inhibitor with an IC50 of 46 µM. PDK4-IN-2 improves ejection fraction of failing hearts by regulating bioenergetics via activation of the tricarboxylic acid cycle[1].
Target Antigen
PDHK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pdk4-in-2.html
Solubility
10 mM in DMSO
Smiles
COC(C1=CC2=C(C(O)=C1)C(C=C(C2=O)C)=O)=O
Molecular Weight
246.22
References & Citations
[1]Kenichi Aizawa, et al. A Potent PDK4 Inhibitor for Treatment of Heart Failure with Reduced Ejection Fraction. Cells. 2023 Dec 30;13(1):87.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157538/PDK4-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157538/
Clinical Information
No Development Reported
CAS Number
1616752-12-5
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
