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SHP2-IN-24

SHP2-IN-24 (compound 111675) is a potent SHP2 inhibitor with an IC50 value of 0.878 µM and a Ki value of 0.118 µM[1].

Product Specifications

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp2-in-24.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(C=C1C2=NN=C(SCC(N[C@@H](C(OC)=O)CC3=CNC4=CC=CC=C43)=O)N2)Cl

Molecular Formula

C23H22ClN5O4S

Molecular Weight

499.97

References & Citations

[1]Mitra R, et al. Identification of new small molecule allosteric SHP2 inhibitor through pharmacophore-based virtual screening, molecular docking, molecular dynamics simulation studies, synthesis and in vitro evaluation. J Biomol Struct Dyn. 2023 Dec 14:1-20.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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