Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

EGFR-TK-IN-1

EGFR-TK-IN-1 (compound 7o) is a potent mutant EGFR inhibitor with IC50 of 8.5 nM an 9.3 nM against EGFRL858R/T790M and EGFRDel19.EGFR-TK-IN-1 showes strong antiproliferative effects against EGFR mutant-driven non-small cell lung cancer (NSCLC) cells and induces cell apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-tk-in-1.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC=CC(N2C(COC3=CC=CC(OC)=C3)=CC4=CN=C(NC5=CC=C(N6CCC(N(C)C)CC6)C=C5)N=C42)=C1)=O

Molecular Formula

C36H39N7O3

Molecular Weight

617.74

References & Citations

[1]Wang C, et al. Design, synthesis and biological evaluation of potent epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors against resistance mutation for lung cancer treatment. Bioorg Chem. 2023 Dec 6;143:107004.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Rabbit Nuclear Factor Kappa B (NF-κB) ELISA Kit
EIA06109Rb 1 Kit

Rabbit Nuclear Factor Kappa B (NF-κB) ELISA Kit

Ask
View Details
Keratin 6A (KRT6A, K6A, KRT6C, KRT6D, CK6C, K6C, CK6D, K6D, Keratin 6C, Keratin 6D)
141149 200 µL

Keratin 6A (KRT6A, K6A, KRT6C, KRT6D, CK6C, K6C, CK6D, K6D, Keratin 6C, Keratin 6D)

Ask
View Details
Anti-C19orf57 Polyclonal Antibody
MF-0068435-01 50 µL

Anti-C19orf57 Polyclonal Antibody

Ask
View Details
Anti-C19orf57 Polyclonal Antibody
MF-0068435-02 100 µL

Anti-C19orf57 Polyclonal Antibody

Ask
View Details
Anti-C19orf57 Polyclonal Antibody
MF-0068435-03 200 µL

Anti-C19orf57 Polyclonal Antibody

Ask
View Details