EGFR-TK-IN-1

EGFR-TK-IN-1 (compound 7o) is a potent mutant EGFR inhibitor with IC50 of 8.5 nM an 9.3 nM against EGFRL858R/T790M and EGFRDel19.EGFR-TK-IN-1 showes strong antiproliferative effects against EGFR mutant-driven non-small cell lung cancer (NSCLC) cells and induces cell apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-tk-in-1.html

Solubility

10 mM in DMSO

Smiles

C=CC(NC1=CC=CC(N2C(COC3=CC=CC(OC)=C3)=CC4=CN=C(NC5=CC=C(N6CCC(N(C)C)CC6)C=C5)N=C42)=C1)=O

Molecular Formula

C36H39N7O3

Molecular Weight

617.74

References & Citations

[1]Wang C, et al. Design, synthesis and biological evaluation of potent epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors against resistance mutation for lung cancer treatment. Bioorg Chem. 2023 Dec 6;143:107004.