NCI-14465
NCI-14465 is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) inhibitor with an IC 50 of 26.4 μM. NCI-14465 can be used in cancer research[1].
Product Specifications
CAS Number
1144534-31-5
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nci-14465.html
Solubility
10 mM in DMSO
Smiles
NC1=NC(NC2=CC=C3C=CC=CC3=C2)=NC(NC4=CC=C(C)C=C4)=N1.Cl
Molecular Formula
C20H19ClN6
Molecular Weight
378.86
References & Citations
[1]Rohilla A, et al. Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP. Microbiol Spectr. 2024 Jan 11;12 (1) :e0201223.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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