NCI-14465

NCI-14465 is an ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) inhibitor with an IC 50 of 26.4 μM. NCI-14465 can be used in cancer research[1].

Product Specifications

CAS Number

[1144534-31-5]

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nci-14465.html

Solubility

10 mM in DMSO

Smiles

NC1=NC(NC2=CC=C3C=CC=CC3=C2)=NC(NC4=CC=C(C)C=C4)=N1.Cl

Molecular Formula

C20H19ClN6

Molecular Weight

378.86

References & Citations

[1]Rohilla A, et al. Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP. Microbiol Spectr. 2024 Jan 11;12 (1) :e0201223.