DA5-HTL

DA5-HTL is a compound combined dasatinib with HaloTag system efficiently inhibits the growth of the cancer cells with GI50 of 1.923 nM[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Autophagy; Bcr-Abl; Src

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/da5-htl.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C(Cl)=CC=C1)NC(C2=CN=C(S2)NC3=CC(N4CCN(CC4)CCOC(NCCOCCOCCOCCOCCOCCCCCCCl)=O)=NC(C)=N3)=O

Molecular Formula

C39H58Cl2N8O8S

Molecular Weight

869.90

References & Citations

[1]Kwak C, et al. Identification of proteomic landscape of drug-binding proteins in live cells by proximity-dependent target ID. Cell Chem Biol. 2022 Dec 15;29 (12) :1739-1753.e6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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