EP3 antagonist 6
EP3 antagonist 6 (compound 5) is a potent, orally and selective EP3 receptor antagonist, with an IC50 of 1.9 nM. EP3 antagonist 6 can inhibits PGE2-induced uterine contraction in pregnant rats[1].
Product Specifications
CAS Number
499149-94-9
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ep3-antagonist-6.html
Solubility
10 mM in DMSO
Smiles
CC(C)C[C@H](C1=CC(C)=CC(C)=C1)NC(C2=C(C=CC(COC3=C(C=CC=C3)C)=C2)CCC(O)=O)=O
Molecular Formula
C31H37NO4
Molecular Weight
487.63
References & Citations
[1]Asada M, et, al. 3- (2-Aminocarbonylphenyl) propanoic acid analogs as potent and selective EP3 receptor antagonists. Part 3: Synthesis, metabolic stability, and biological evaluation of optically active analogs. Bioorg Med Chem. 2010 May 1;18 (9) :3212-23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP
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