PR antagonist 1

PR antagonist 1 (compound 8) is a selective progesterone receptor (PR) antagonist, and can be used for the research of a variety of progesterone-related diseases and disorders such as endometriosis and uterine fibroids[1].

Product Specifications

CAS Number

[936345-34-5]

UNSPSC

12352005

Target

Progesterone Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/pr-antagonist-1.html

Purity

99.71

Solubility

10 mM in DMSO

Smiles

N#CC1=C(C)C=C(OC2=C(C3CC3)N(CS(=O)(C)=O)N=C2C)C=C1C

Molecular Formula

C18H21N3O3S

Molecular Weight

359.44

References & Citations

[1]Paul A, et al. Development of a Practical Synthesis of the Progesterone Receptor Antagonist 4-{[3-Cyclopropyl-1- (mesylmethyl) -5-methyl-1H-pyrazol-4-yl]oxy}-2,6-dimethylbenzonitrile, Organic Process Research & Development 2009 13 (5), 848-853.