K2-B4-5e
K2-B4-5e is a E3 ligase KLHDC2-based BRD4 and androgen receptor (AR) degradation PROTAC. K2-B4-5e is capable of inducing rapid and robust degradation of BET-family and AR proteins in cells[1].
Product Specifications
CAS Number
[3093556-90-9]
UNSPSC
12352005
Target
Androgen Receptor; Epigenetic Reader Domain; PROTACs
Type
Reference compound
Related Pathways
Epigenetics; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k2-b4-5e.html
Solubility
10 mM in DMSO
Smiles
O=C(C[C@@H]1N=C(C2=C(N3C(C)=NN=C13)SC(C)=C2C)C4=CC=C(C=C4)Cl)NC5=CC=C(C=C5)C6=CC=C(C=C6)C(N7CCC8=C(N(C(C(CC(C)C)=C8)=O)C9=CN(C(C=C9)=O)CC(OC)=O)C7)=O
Molecular Formula
C52H49ClN8O6S
Molecular Weight
949.51
References & Citations
[1]Christopher M Hickey, et al. Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules. Nat Struct Mol Biol. 2024 Jan 4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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