PARP/HDAC-IN-1

PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of PARP and HDAC. PARP/HDAC-IN-1 inhibits PARP1, PARP2 and HDAC1 with IC50s of 19.01, 2.13, 1690 nM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

HDAC; PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp-hdac-in-1.html

Solubility

10 mM in DMSO

Smiles

FC(C(C(N1CCN(CC1)CC2=CC=C(C=C2)/C=C/C(NC3=C(C=C(C=C3)F)N)=O)=O)=C4)=CC=C4CC5=NNC(C6=C5C=CC=C6)=O

Molecular Formula

C36H32F2N6O3

Molecular Weight

634.67

References & Citations

[1]Zhu Q, et al. Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer. Cell Death Dis. 2024 Jan 5;15 (1) :10.