PARP/HDAC-IN-1
Product Specifications
UNSPSC Description
PARP/HDAC-IN-1 (compound B102) is a potent dual inhibitor of PARP and HDAC. PARP/HDAC-IN-1 inhibits PARP1, PARP2 and HDAC1 with IC50s of 19.01, 2.13, 1690 nM, respectively[1].
Target Antigen
HDAC; PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp-hdac-in-1.html
Solubility
10 mM in DMSO
Smiles
FC(C(C(N1CCN(CC1)CC2=CC=C(C=C2)/C=C/C(NC3=C(C=C(C=C3)F)N)=O)=O)=C4)=CC=C4CC5=NNC(C6=C5C=CC=C6)=O
Molecular Weight
634.67
References & Citations
[1]Zhu Q, et al. Novel dual inhibitors of PARP and HDAC induce intratumoral STING-mediated antitumor immunity in triple-negative breast cancer. Cell Death Dis. 2024 Jan 5;15(1):10.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157490/PARP-HDAC-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157490/
Clinical Information
No Development Reported
Curated Selection
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