P-gp inhibitor 19
P-gp inhibitor 19 (Compound 6i) is a P-gp inhibitor. P-gp inhibitor 19 can inhibit the efflux of rhodamine 123 (HY-D0816) in P-gp-overexpressing leukemia cells K562/Dox and also restore the sensitivity of DOX-resistant cells[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-19.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CC[C@]3([C@@]([C@@]1(CC[C@]4(C(C)(C)[C@H](CC[C@]24C)O)[H])C)(C)CC[C@]5(CC[C@H]([C@@]53[H])C(C)=C)COC(N6CCN(C)CC6)=O)[H]
Molecular Formula
C36H60N2O3
Molecular Weight
568.87
References & Citations
[1]Laiolo J, Graikioti D G, Barbieri C L, et al. Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein[J]. Scientific Reports, 2024, 14 (1) : 70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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