P-gp inhibitor 18
P-gp inhibitor 18 (compound 6G) is a potent inhibitor of P-glycoprotein (P-gp). P-gp inhibitor 18 inhibits rhodamine 123 efflux in the P-gp overexpressed leukemia cells, K562/Dox[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-18.html
Solubility
10 mM in DMSO
Smiles
[H][C@]12CC[C@]3([C@@]([C@@]1(CC[C@]4(C(C)(C)[C@H](CC[C@]24C)O)[H])C)(C)CC[C@]5(CC[C@H]([C@@]53[H])C(C)=C)COC(NCCC6=CC(OC)=C(C(OC)=C6)OC)=O)[H]
Molecular Formula
C42H65NO6
Molecular Weight
679.97
References & Citations
[1]Laiolo J, et al. Novel betulin derivatives as multidrug reversal agents targeting P-glycoprotein. Sci Rep. 2024 Jan 2;14 (1) :70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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