HDAC1-IN-6
HDAC1-IN-6 (compound 1) is an inhibitor of HDAC1 and 11, with an IC50 of 1.9 μM and 1.6 μM, respectively. HDAC1-IN-6 induces differentiation in AML cells[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac1-in-6.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=C(N)C=CC=C1)[C@@H]2CC[C@H](CC2)CNC3=NC=CC(C4=CC=CN=C4)=N3
Molecular Formula
C23H26N6O
Molecular Weight
402.49
References & Citations
[1]Purnima Kumar, et al. HDAC inhibitor derivatives induce differentiation of leukemic cells through two distinct and separable mechanisms.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC2; HDAC6
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