Z21090

Z21090 (ZL40) is a potent inhibitor of PDE4 with the IC50 value of 37.4 nM and oral bioavailability. Z21090 plays an important role in alcohol-related diseases research[1].

Product Specifications

CAS Number

2992690-71-6

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/z21090.html

Solubility

10 mM in DMSO

Smiles

CCOC1=NC(Cl)=CC2=C1C=NN2CCCC(O)=O

Molecular Formula

C12H14ClN3O3

Molecular Weight

283.71

References & Citations

[1]Lei Zheng, et al. Discovery of 4-Ethoxy-6-chloro-5-azaindazoles as Novel PDE4 Inhibitors for the Treatment of Alcohol Use Disorder and Alcoholic Liver Diseases. J Med Chem. 2023 Dec 29.