AR antagonist 5
AR antagonist 5 (compound 30a) is a selective androgen receptor (AR) antagonist with an IC50 value of 134.8 nM. AR antagonist 5 has favorable pharmacokinetic properties and shows a high skin exposure and low plasma exposure[1.
Product Specifications
CAS Number
2902679-53-0
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-antagonist-5.html
Solubility
10 mM in DMSO
Smiles
C[C@](CN1CC2CC(N2C3=CC=C(C=C3)C#N)C1)(C(NC4=CN=C(C(C(F)(F)F)=C4)C#N)=O)O
Molecular Formula
C23H21F3N6O2
Molecular Weight
470.45
References & Citations
[1]Wenqiang Zhang, et al. Discovery of (2 S) - N- (6-Cyano-5- (trifluoromethyl) pyridin-3-yl) -3- (6- (4-cyanophenyl) -3,6-diazabicyclo[3.1.1]heptan-3-yl) -2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. J Med Chem. 2024, 67,1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
A3575-02 200 µL
ACTR3B, CT (Actin-related Protein 3B, Actin-like Protein 3B, ARP3-beta, Actin-related Protein ARP4, ARP4, ARP11)
Sign In for Pricing
View Details 
