AR antagonist 5

AR antagonist 5 (compound 30a) is a selective androgen receptor (AR) antagonist with an IC50 value of 134.8 nM. AR antagonist 5 has favorable pharmacokinetic properties and shows a high skin exposure and low plasma exposure[1.

Product Specifications

CAS Number

[2902679-53-0]

UNSPSC

12352005

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ar-antagonist-5.html

Solubility

10 mM in DMSO

Smiles

C[C@](CN1CC2CC(N2C3=CC=C(C=C3)C#N)C1)(C(NC4=CN=C(C(C(F)(F)F)=C4)C#N)=O)O

Molecular Formula

C23H21F3N6O2

Molecular Weight

470.45

References & Citations

[1]Wenqiang Zhang, et al. Discovery of (2 S) - N- (6-Cyano-5- (trifluoromethyl) pyridin-3-yl) -3- (6- (4-cyanophenyl) -3,6-diazabicyclo[3.1.1]heptan-3-yl) -2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. J Med Chem. 2024, 67,1.