AR antagonist 5
AR antagonist 5 (compound 30a) is a selective androgen receptor (AR) antagonist with an IC50 value of 134.8 nM. AR antagonist 5 has favorable pharmacokinetic properties and shows a high skin exposure and low plasma exposure[1.
Product Specifications
CAS Number
2902679-53-0
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar-antagonist-5.html
Solubility
10 mM in DMSO
Smiles
C[C@](CN1CC2CC(N2C3=CC=C(C=C3)C#N)C1)(C(NC4=CN=C(C(C(F)(F)F)=C4)C#N)=O)O
Molecular Formula
C23H21F3N6O2
Molecular Weight
470.45
References & Citations
[1]Wenqiang Zhang, et al. Discovery of (2 S) - N- (6-Cyano-5- (trifluoromethyl) pyridin-3-yl) -3- (6- (4-cyanophenyl) -3,6-diazabicyclo[3.1.1]heptan-3-yl) -2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. J Med Chem. 2024, 67,1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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