5,3',4',3'',4'',5''-6-O-Ethyl-EGCG
5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) is a potent adjuvant obtained by optimization of the structure of EGCG. 5,3',4',3'',4'',5''-6-O-Ethyl-EGCG (Y6) decreases the expression of HIF-1α and CBR1 at both the mRNA and protein levels[1].
Product Specifications
CAS Number
1613308-63-6
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/5-3-4-3-4-5-6-o-ethyl-egcg.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OCC)=C(C(OCC)=C1)OCC)O[C@H]2[C@@H](C3=CC(OCC)=C(C(O)=C3)OCC)OC4=CC(O)=CC(OCC)=C4C2
Molecular Formula
C34H42O11
Molecular Weight
626.69
References & Citations
[1]Huan Zhou, et al. The epigallocatechin gallate derivative Y6 reduces the cardiotoxicity and enhances the efficacy of daunorubicin against human hepatocellular carcinoma by inhibiting carbonyl reductase 1 expression. J Ethnopharmacol. 2020 Oct 28:261:113118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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