Myt1-IN-4
Myt1-IN-4 (21) is an orally active and selective membrane-associated tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1) (Gene name PKMYT1) inhibitor, with an IC50 of 2.6 nM. Myt1-IN-4 (21) possesses antitumor activity[1].
Product Specifications
UNSPSC
12352005
Target
Wee1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/myt1-in-4-1.html
Solubility
10 mM in DMSO
Smiles
NC([N@@]1[C@@]2=C(C=CC(O)=C2C)C)=C(C3=NC(C4CC4)=C(N=C31)C)C(N5CCN6N=CC=C6C5)=O
Molecular Formula
C25H27N7O2
Molecular Weight
457.53
References & Citations
[1]Yazhou Wang, et al. Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer. J Med Chem. 2024 Jan 11;67 (1) :420-432.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKMYT1
Frequently Asked Questions
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