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Myt1-IN-4

Myt1-IN-4 (21) is an orally active and selective membrane-associated tyrosine and threonine-specific cdc2-inhibitory kinase (Myt1) (Gene name PKMYT1) inhibitor, with an IC50 of 2.6 nM. Myt1-IN-4 (21) possesses antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Wee1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/myt1-in-4-1.html

Solubility

10 mM in DMSO

Smiles

NC([N@@]1[C@@]2=C(C=CC(O)=C2C)C)=C(C3=NC(C4CC4)=C(N=C31)C)C(N5CCN6N=CC=C6C5)=O

Molecular Formula

C25H27N7O2

Molecular Weight

457.53

References & Citations

[1]Yazhou Wang, et al. Discovery of Tetrahydropyrazolopyrazine Derivatives as Potent and Selective MYT1 Inhibitors for the Treatment of Cancer. J Med Chem. 2024 Jan 11;67 (1) :420-432.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PKMYT1

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