AChE/Aβ-IN-3
Product Specifications
UNSPSC Description
AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with IC50 values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease[1].
Target Antigen
Amyloid-β; Cholinesterase (ChE); Reactive Oxygen Species
Type
Reference compound
Related Pathways
Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling;NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-aβ-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C(F)(F)F)=C1)CN2CCN(C3=CC(NC4=C3C=CC=C4)=O)CC2
Molecular Weight
430.42
References & Citations
[1]Manzoor S, et al. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS Chem Neurosci. 2023 Dec 27.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157440/AChE-Aβ-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157440/
Clinical Information
No Development Reported
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