AChE/Aβ-IN-3

AChE/Aβ-IN-3 (compound AM5) is a dual inhibitor of AChE and Amyloid-β aggregation with IC50 values of 1.29 and 4.93 μM, respectively. AChE/Aβ-IN-3 has antioxidant properties that scavenge ROS and restore their normal levels. AChE/Aβ-IN-3 can be used in the study of neurological diseases, such as Alzheimer's disease[1].

Product Specifications

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE) ; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-aβ-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC(C(F)(F)F)=C1)CN2CCN(C3=CC(NC4=C3C=CC=C4)=O)CC2

Molecular Formula

C22H21F3N4O2

Molecular Weight

430.42

References & Citations

[1]Manzoor S, et al. Discovery of Quinolinone Hybrids as Dual Inhibitors of Acetylcholinesterase and Aβ Aggregation for Alzheimer's Disease Therapy. ACS Chem Neurosci. 2023 Dec 27.