PCSK9-IN-23

PCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression[1].

Product Specifications

CAS Number

[2115700-96-2]

UNSPSC

12352005

Target

PCSK9

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pcsk9-in-23.html

Concentration

10mM

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C=C(NCC2=CC=C(C(F)(F)F)C=C2)C=C(C)N1CC3=CC=C(C(F)(F)F)C=C3

Molecular Formula

C22H18F6N2O

Molecular Weight

440.38

References & Citations

[1]Lisa Giannessi, et al. Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability. Eur J Med Chem. 2023 Dec 20:265:116063.