PCSK9-IN-23
PCSK9-IN-23 (compound 5C) is a potent PCSK9 inhibitor. PCSK9-IN-23 blocks PCSK9 secretion from HepG2 cells, significantly increases LDL receptor (LDLR) expression[1].
Product Specifications
CAS Number
[2115700-96-2]
UNSPSC
12352005
Target
PCSK9
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pcsk9-in-23.html
Concentration
10mM
Purity
99.57
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C=C(NCC2=CC=C(C(F)(F)F)C=C2)C=C(C)N1CC3=CC=C(C(F)(F)F)C=C3
Molecular Formula
C22H18F6N2O
Molecular Weight
440.38
References & Citations
[1]Lisa Giannessi, et al. Identification of 4-amino-2-Pyridones as new potent PCSK9 inhibitors: From phenotypic hit discovery to in vivo tolerability. Eur J Med Chem. 2023 Dec 20:265:116063.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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