EGFR-IN-97
EGFR-IN-97 (compound 6q) is a EGFR inhibitor. EGFR-IN-97 shows inhibitory activity against Ba/F3-EGFRL858R/T790M/C797S and Ba/F3-EGFRDel19/T790M/C797S cells, with IC50 values of 0.42 μM and 0.41 μM, respectively. EGFR-IN-97 can promote apoptosis of NCI-H1975-EGFRL858R/T790M/C797S cells at the concentration of 0.8 μM[1].
Product Specifications
CAS Number
3020681-05-1
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-97.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=CC(NC(C=C2)=CC=C2NC([C@@H](C3=CC=CC=C3)N4CC5=CC(C6=CC=C(N7CCN(CC7)C)C=C6)=CC=C5C4=O)=O)=N1
Molecular Formula
C37H36N8O2
Molecular Weight
624.73
References & Citations
[1]Hu L, et al. Identification of novel aminopyrimidine derivatives for the treatment of mutant NSCLC. Eur J Med Chem. 2023 Dec 20;265:116074.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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