5-HT2CR agonist 1

5-HT2CR agonist 1 (compound 8), a 7-chloro analogue, is a selective 5-HT2CR partial agonist (Emax=71.09%) with an EC50 value of 121.5 nM and no observed activity toward 5-HT2AR or 5-HT2BR. 5-HT2CR agonist 1 exhibits no recruitment activity for β-arrestin and shows low inhibition of hERG at 10 μM[1].

Product Specifications

CAS Number

[1216074-15-5]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ht2cr-agonist-1.html

Solubility

10 mM in DMSO

Smiles

ClC1=CC=C2C=CC3(OC2=C1)CCNCC3

Molecular Formula

C13H14ClNO

Molecular Weight

235.71

References & Citations

[1]Guangqian Jiang, et al Identification of Spiro[chromene-2,4′-piperidine]s as Potent, Selective, and Gq-Biased 5-HT2C Receptor Partial Agonists. ACS Med. Chem. Lett. December 18, 2023.