Nampt activator-4

Nampt activator-4 is a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of 0.058 μM. Nampt activator-4 can enhance the nicotinamide adenine dinucleotide (NAD+) in cells[1].

Product Specifications

CAS Number

[2847156-05-0]

UNSPSC

12352005

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/nampt-activator-4.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1CN(CCN1)C2=NC=NC3=NN(C=C32)C4=CC=C(C=C4)C(F)(F)F)NCC5=CC=C6SC=CC6=C5

Molecular Formula

C26H22F3N7OS

Molecular Weight

537.56

References & Citations

[1]Shen, Zhengnan et al. Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs) . Journal of medicinal chemistry vol. 66,24 (2023) : 16704-16727.