Nampt activator-4
Nampt activator-4 is a positive allosteric modulator (N-PAM) of nicotinamide phosphoribosyltransferase (NAMPT) with an EC50 of 0.058 μM. Nampt activator-4 can enhance the nicotinamide adenine dinucleotide (NAD+) in cells[1].
Product Specifications
CAS Number
2847156-05-0
UNSPSC
12352005
Target
NAMPT
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/nampt-activator-4.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H]1CN(CCN1)C2=NC=NC3=NN(C=C32)C4=CC=C(C=C4)C(F)(F)F)NCC5=CC=C6SC=CC6=C5
Molecular Formula
C26H22F3N7OS
Molecular Weight
537.56
References & Citations
[1]Shen, Zhengnan et al. Synthesis, Optimization, and Structure-Activity Relationships of Nicotinamide Phosphoribosyltransferase (NAMPT) Positive Allosteric Modulators (N-PAMs) . Journal of medicinal chemistry vol. 66,24 (2023) : 16704-16727.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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