FL77-24

FL77-24, a FL118 analog and apoptosis inducer, possesses antitumor activity, with IC50 values of 99.4 nM, 118 nM, [1].

Product Specifications

CAS Number

[2413582-39-3]

Product Name Alternative

7- (4-Ethylphenyl) -FL118

UNSPSC

12352005

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fl77-24.html

Solubility

10 mM in DMSO

Smiles

CC[C@]1(C(OCC2=C1C=C3C4=NC5=C(C(C6=CC(OC)=CC(OC)=C6)=C4CN3C2=O)C=C7OCOC7=C5)=O)O

Molecular Formula

C29H24N2O8

Molecular Weight

528.51

References & Citations

[1]Wenchao Wang, et al. Structure-Activity Relationship of FL118 Platform Position 7 Versus Position 9-Derived Compounds and Their Mechanism of Action and Antitumor Activity. J Med Chem. 2023 Dec 28;66 (24) :16888-16916.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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