Topoisomerase II/EGFR-IN-1
Selected Variant
HY-157402
Size: 1 Each
Topoisomerase II/EGFR-IN-1 is topoisomerase II/EGFR dual inhibitor. Topoisomerase II/EGFR-IN-1 has superior cytotoxic activity to MCF-7, A549 and HCT-116 cell lines, displays strong apoptotic activity and can be used for the research of cancer[1].
Product Specifications
UNSPSC
12352005
Target
EGFR; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-egfr-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C2=O)C=CC=C1)C3=C2SC4=NC(C(C=C5)=CC=C5[N+]([O-])=O)=C(C#N)C(N43)=O
Molecular Formula
C21H8N4O5S
Molecular Weight
428.38
References & Citations
[1]Mourad M A E, et al. Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho [2′, 3′: 4, 5] thiazolo [3, 2-a] pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity [J]. Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38 (1) : 2205043.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
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