EGFR/HER2-IN-10
EGFR/HER2-IN-10 (compound 9F) is a potent and selective dual EGFR/HER2 inhibitor with IC50s of 2.3 nM and 234 nM for EGFR and HER2, respectively. EGFR/HER2-IN-10 shows an effective antiproliferative action against prostate carcinoma[1].
Product Specifications
CAS Number
2931499-82-8
UNSPSC
12352005
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-her2-in-10.html
Solubility
10 mM in DMSO
Smiles
O=[N+](C1=NC=CN1CCCCOC2=CC3=C(NC4=CC=C(OC5=CC=CC(C(F)(F)F)=C5)C(Cl)=C4)N=CN=C3C=C2OC)[O-]
Molecular Formula
C29H24ClF3N6O5
Molecular Weight
628.99
References & Citations
[1]Seohyun Son, et al. Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2202358.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; ErbB2/HER2
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