ALK/ROS1-IN-3
Product Specifications
UNSPSC Description
ALK/ROS1-IN-3 (compound C01) is a ROS1 and ALK dual inhibitor with IC50s of 42.3 nM and 49.1 nM for ROS1G2032R and ALKG1202R, respectively[1].
Target Antigen
Anaplastic lymphoma kinase (ALK); ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk-ros1-in-3.html
Solubility
10 mM in DMSO
Smiles
NC(N=CC(C1=CC2=C(NC(C23CCN(CC3)C)=O)C=C1)=C4)=C4O[C@H](C)C5=CC=CC=C5C6=CC=CC=C6
Molecular Weight
504.62
References & Citations
[1]Siming Liu, et al. Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2227779.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157391/ALK-ROS1-IN-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157391/
Clinical Information
No Development Reported
Curated Selection
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