ALK/ROS1-IN-3
ALK/ROS1-IN-3 (compound C01) is a ROS1 and ALK dual inhibitor with IC50s of 42.3 nM and 49.1 nM for ROS1G2032R and ALKG1202R, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Anaplastic lymphoma kinase (ALK) ; ROS Kinase
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk-ros1-in-3.html
Solubility
10 mM in DMSO
Smiles
NC(N=CC(C1=CC2=C(NC(C23CCN(CC3)C)=O)C=C1)=C4)=C4O[C@H](C)C5=CC=CC=C5C6=CC=CC=C6
Molecular Formula
C32H32N4O2
Molecular Weight
504.62
References & Citations
[1]Siming Liu, et al. Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2227779.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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