AK-HW-90
AK-HW-90 (compound 2B) is a potent panBcr-Abl inhibitor with significant inhibitory activity against Imatinib -resistant mutants. AK-HW-90 inhibits the resistance mutant Bcr-AblT315I with an IC50 of 0.65 nM. AK-HW-90 has potential anticancer activity and can be used in the study of chronic myelogenous leukemia (CML).
Product Specifications
UNSPSC
12352005
Target
Bcr-Abl
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ak-hw-90.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=C(C=C1)N2CCN(CC2)CC)NC(S3)=NC(C3=C4)=CC=C4C(C=CC=C5)=C5OC
Molecular Formula
C27H29N5O2S
Molecular Weight
487.62
References & Citations
[1]El-Damasy AK, et al. Overcoming the imatinib-resistant BCR-ABL mutants with new ureidobenzothiazole chemotypes endowed with potent and broad-spectrum anticancer activity. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2189097.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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