HDAC-IN-67

HDAC-IN-67 (compound 27f) is an HDAC inhibitor against HDAC1 and HDAC6, with IC50 values of 22 nM and 8 nM, respectively. HDAC-IN-67 inhibits cell proliferation and induces cell apoptosis. HDAC-IN-67 exhibits antitumor activity[1].

Product Specifications

CAS Number

[2821923-75-3]

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac-in-67.html

Solubility

10 mM in DMSO

Smiles

ONC(CCCCCCC(N1CCN(CC1)CC([C@@H]2CC[C@](C=C)(C)[C@H](C(CN3N=CC=C3)=C)C2)=C)=O)=O

Molecular Formula

C30H47N5O3

Molecular Weight

525.73

References & Citations

[1]Gao Y, et al., Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2195991.