BChE-IN-22
BChE-IN-22 (compound 5A) is a selective eqBChE inhibitor (IC50: 0.53 μM), has anti-inflammatory and neuroprotective activities. BChE-IN-22 can inhibit cell damage caused by Aβ25-35 and improve cognitive dysfunction caused by Scopolamine (HY-N0296).
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bche-in-22.html
Solubility
10 mM in DMSO
Smiles
CN(C(OC1=CC(OC(N(C)C)=O)=C(C=C1)C(N2CCC(CC2)CC3=CC=CC=C3)=O)=O)C
Molecular Formula
C25H31N3O5
Molecular Weight
453.53
References & Citations
[1]Zhou Y, et al. Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2231661.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE
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