BChE-IN-22

BChE-IN-22 (compound 5A) is a selective eqBChE inhibitor (IC50: 0.53 μM), has anti-inflammatory and neuroprotective activities. BChE-IN-22 can inhibit cell damage caused by Aβ25-35 (HY-P0128) and improve cognitive dysfunction caused by Scopolamine (HY-N0296) [1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bche-in-22.html

Solubility

10 mM in DMSO

Smiles

CN(C(OC1=CC(OC(N(C)C)=O)=C(C=C1)C(N2CCC(CC2)CC3=CC=CC=C3)=O)=O)C

Molecular Formula

C25H31N3O5

Molecular Weight

453.53

References & Citations

[1]Zhou Y, et al. Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2231661.