NHS-Ala-Ala-Asn-active metabolite
Product Specifications
UNSPSC Description
NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP)inhibitor[1].
Target Antigen
ADC Linker; Kinesin
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nhs-ala-ala-asn-active-metabolite.html
Solubility
10 mM in DMSO
Smiles
O=C(CCC1=O)N1OC(CCCC(N[C@@H](C)C(N(C)[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCCC(N[C@@H](C(O)=O)CCC(O)=O)=O)=O)CCN(C(CO)=O)[C@@H](C2=CC(C3=C(C=CC(F)=C3)F)=CN2CC4=CC=CC=C4)C(C)(C)C)=O)=O)=O)=O)=O
Molecular Weight
1195.22
References & Citations
[1]Lerchen HG, et al. Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads. Bioconjug Chem. 2020;31(8):1893-1898.
|[2]Lerchen HG, et al. Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads. Bioconjug Chem. 2020;31(8):1893-1898.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157338/NHS-Ala-Ala-Asn-active-metabolite-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157338/
Clinical Information
No Development Reported
CAS Number
2231135-69-4
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