NHS-Ala-Ala-Asn-active metabolite

NHS-Ala-Ala-Asn-active metabolite is a cleavable antibody-drug conjugate (ADC) linker for synthesis of kinesin spindle protein (KSP) inhibitor[1].

Product Specifications

CAS Number

[2231135-69-4]

UNSPSC

12352203

Target

ADC Linker; Kinesin

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nhs-ala-ala-asn-active-metabolite.html

Solubility

10 mM in DMSO

Smiles

O=C(CCC1=O)N1OC(CCCC(N[C@@H](C)C(N(C)[C@@H](C)C(N[C@@H](CC(N)=O)C(N[C@H](C(NCCC(N[C@@H](C(O)=O)CCC(O)=O)=O)=O)CCN(C(CO)=O)[C@@H](C2=CC(C3=C(C=CC(F)=C3)F)=CN2CC4=CC=CC=C4)C(C)(C)C)=O)=O)=O)=O)=O

Molecular Formula

C56H72F2N10O17

Molecular Weight

1195.22

References & Citations

[1]Lerchen HG, et al. Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads. Bioconjug Chem. 2020;31 (8) :1893-1898. |[2]Lerchen HG, et al. Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads. Bioconjug Chem. 2020;31 (8) :1893-1898.