P-gp inhibitor 16
P-gp inhibitor 16 (compound 14) is a p-glycoprotein inhibitor. P-gp inhibitor 16 significantly increases Doxorubicin-induced apoptosis and shows anticancer effects[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; P-glycoprotein
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-16.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC=C1NC2=NC=NC3=CC=C(C=C32)C4=CC=C(C=C4)C(NCCN5CCC6=CC(OC)=C(C=C6C5)OC)=O
Molecular Formula
C35H35N5O4
Molecular Weight
589.68
References & Citations
[1]Wen-Han Xue, et al. Discovery of (quinazolin-6-yl) benzamide derivatives containing a 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety as potent reversal agents against P-glycoprotein-mediated multidrug resistance. Eur J Med Chem. 2023 Dec 12:264:116039.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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