EGFR-IN-94
Product Specifications
UNSPSC Description
EGFR-IN-94 (compound 5a) is a EGFR inhibitor with IC50 of 0.086 μM, and also has IC50 of 0.107μM and 2.52 μM for VEGFR-2 and Topo II, respectively. EGFR-IN-94 induces cell apoptosis and arrests cell cycle at the S phase in HepG-2 cells [1].
Target Antigen
Apoptosis; EGFR; VEGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-94.html
Solubility
10 mM in DMSO
Smiles
CC1=C(N=NN1CC2=NC3=CC=CC=C3N2)C(NNC(NC4=CC=C(Cl)C=C4)=S)=O
Molecular Weight
440.91
References & Citations
[1]Othman DIA, et al. Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies. J Enzyme Inhib Med Chem. 2023;38(1):2166037.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157324/EGFR-IN-94-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157324/
Clinical Information
No Development Reported
Curated Selection
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