EGFR-IN-94

EGFR-IN-94 (compound 5a) is a EGFR inhibitor with IC50 of 0.086 μM, and also has IC50 of 0.107μM and 2.52 μM for VEGFR-2 and Topo II, respectively. EGFR-IN-94 induces cell apoptosis and arrests cell cycle at the S phase in HepG-2 cells [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR; VEGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/egfr-in-94.html

Solubility

10 mM in DMSO

Smiles

CC1=C(N=NN1CC2=NC3=CC=CC=C3N2)C(NNC(NC4=CC=C(Cl)C=C4)=S)=O

Molecular Formula

C19H17ClN8OS

Molecular Weight

440.91

References & Citations

[1]Othman DIA, et al. Identification of new benzimidazole-triazole hybrids as anticancer agents: multi-target recognition, in vitro and in silico studies. J Enzyme Inhib Med Chem. 2023;38 (1) :2166037.