HDAC6-IN-28

HDAC6-IN-28 (compound 10C) is a potent inhibitor of HDAC6 with an IC50 of 261 nM. HDAC6-IN-28 significantly induces apoptosis and S-phase arrest in B16-F10 cells. HDAC6-IN-28 efficiently increases the expression of acetylated-α-tubulin in vitro and in vivo[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac6-in-28.html

Solubility

10 mM in DMSO

Smiles

FC(N=C1C=CC=CC1=C23)=C3C4=CC=CC=C4N2CC5=CC=C(C=C5)C(NO)=O

Molecular Formula

C23H16FN3O2

Molecular Weight

385.39

References & Citations

[1]Peng X, et al. Discovery of novel benzohydroxamate-based histone deacetylase 6 (HDAC6) inhibitors with the ability to potentiate anti-PD-L1 immunotherapy in melanoma. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2201408.