PI3Kα-IN-15
PI3Kα-IN-15 is a potent PI3Kα inhibitor with an IC50 of 0.15 μM. PI3Kα-IN-15 also has acceptable anti-proliferative activity (inhibits SKOV-3, T47D, NCI-H1975, NCI-H460, and MCF-7 growth with IC50 values of 26.6 μM, 7.9 μM, 32.1 μM, 17.7 μM, and 9.4 μM, respectively. PI3Kα-IN-15 can be used for cancer research[1].
Product Specifications
CAS Number
2893920-80-2
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-15.html
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(F)C=C1)(NC2=CC(C3=CC(C)=CN4C3=NC(C(N5CCCC5)=O)=C4)=CN=C2OC)=O
Molecular Formula
C25H24FN5O4S
Molecular Weight
509.55
References & Citations
[1]Rui Chen, et al. Design, synthesis and evaluation of 2, 6, 8-substituted Imidazopyridine derivatives as potent PI3K α inhibitors. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :2155638.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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