PB17-026-01

PB17-026-01 is a potent SHP2 allosteric inhibitor and shows the highest inhibitory activity with an IC50 value of 38.9 nM. PB17-026-01 can be used for the research of tumor[1].

Product Specifications

UNSPSC

12352005

Target

SHP2

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pb17-026-01.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C)C(N(CC2)CCC32[C@@H](N)[C@@H](C)OC3)=NN4C1=C(C5=CC=CC(Cl)=C5Cl)C=C4

Molecular Formula

C22H25Cl2N5O2

Molecular Weight

462.37

References & Citations

[1]Luo Y, et al. Discovery of the SHP2 allosteric inhibitor 2- ((3R,4R) -4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl) -5- (2,3-dichlorophenyl) -3-methylpyrrolo[2,1-f][1,2,4] triazin-4 (3H) -one. J Enzyme Inhib Med Chem. 2023 Dec;38 (1) :398-404.