PB17-026-01
Product Specifications
UNSPSC Description
PB17-026-01 is a potent SHP2 allosteric inhibitor and shows the highest inhibitory activity with an IC50 value of 38.9 nM. PB17-026-01 can be used for the research of tumor[1].
Target Antigen
SHP2
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pb17-026-01.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C)C(N(CC2)CCC32[C@@H](N)[C@@H](C)OC3)=NN4C1=C(C5=CC=CC(Cl)=C5Cl)C=C4
Molecular Weight
462.37
References & Citations
[1]Luo Y, et al. Discovery of the SHP2 allosteric inhibitor 2-((3R,4R)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-5-(2,3-dichlorophenyl)-3-methylpyrrolo[2,1-f][1,2,4] triazin-4(3H)-one. J Enzyme Inhib Med Chem. 2023 Dec;38(1):398-404.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157318/PB17-026-01-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157318/
Clinical Information
No Development Reported
Curated Selection
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