TM38837
CB1 antagonist 4 is a inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. CB1 antagonist 4 can reduce body weight, improve plasma inflammatory markers and glucose homeostasis[1].
Product Specifications
CAS Number
1034264-77-1
UNSPSC
12352005
Target
Cannabinoid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tm38837-1.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=CC=C([C@@H](C)NC(C2=NN(C3=CC=CC=C3Cl)C(C4=CC=C(Cl)C=C4)=C2CC5=NNN=N5)=O)C=C1)F
Molecular Formula
C27H20Cl2F3N7O
Molecular Weight
586.40
References & Citations
[1]Högberg T, et al. Optimizing and characterizing 4-methyl substituted pyrazol-3-carboxamides leading to the peripheral cannabinoid 1 receptor inverse agonist TM38837. Bioorg Med Chem Lett. 2023 Dec 1;98:129572.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CB1
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