SSTR5 antagonist 3
SSTR5 antagonist 3 (Compound 23) is an orally active somatostatin receptor subtype 5 (SSTR5) antagonist with low hERG inhibition. SSTR5 antagonist 3 exhibits potency with IC50 values of 2.8 nM and 1.4 nM in human and mouse, respectively. SSTR5 antagonist 3 can be used for the research of anti-gallstone[1].
Product Specifications
CAS Number
2851454-42-5
UNSPSC
12352005
Target
Somatostatin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sstr5-antagonist-3.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(C2=C(C=C(C=C2OCC)CN3CCC(F)(CC3)CNC4=CC(OC)=C(C(O)=O)C=C4)OCC)C=C1
Molecular Formula
C31H36F2N2O5
Molecular Weight
554.62
References & Citations
[1]Han F, et al. Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones. Eur J Med Chem. 2023 Dec 5;264:116017.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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