C-Met-IN-21
C-Met-IN-21 (compound 54) is a c-met inhibitor with an IC50 value of 0.45 nM, and shows anti-tumor efficacy in vivo[1].
Product Specifications
CAS Number
[3025958-01-1]
UNSPSC
12352005
Target
C-Met/HGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/c-met-in-21.html
Solubility
10 mM in DMSO
Smiles
FC(F)(C1=NN=C2C=CC(C(C=C3CC4)=CC=C3N(CC(N5CCN(C(C)C)CC5)=O)C4=O)=NN12)C6=CC=C7C(C=CC=N7)=C6
Molecular Formula
C33H32F2N8O2
Molecular Weight
610.66
References & Citations
[1]Min W, et al. Discovery of potent and selective c-Met inhibitors for MET-amplified hepatocellular carcinoma treatment. Eur J Med Chem. Published online December 5, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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