HL403
Product Specifications
UNSPSC Description
HL403 is a potent and dual BRD4/Src inhibitor. HL403 has IC50 values of 133 nM for BRD4 inhibition and 4.5 nM for Src inhibition. HL403 shows anti-cancer activity[1].
Target Antigen
Epigenetic Reader Domain; Src
Type
Reference compound
Related Pathways
Epigenetics;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hl403.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(N[C@@H](C)C(OCCN5CCN(CC5)C6=NC(C)=NC(NC7=NC=C(S7)C(NC8=C(C=CC=C8Cl)C)=O)=C6)=O)=O
Molecular Weight
941.95
References & Citations
[1]Wang Y, et al. Design and synthesis of dual BRD4/Src inhibitors for treatment of triple-negative breast cancer. Eur J Med Chem. 2023 Nov 29;264:116009.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-157290/HL403-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-157290/
Clinical Information
No Development Reported
Curated Selection
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