HL403

HL403 is a potent and dual BRD4/Src inhibitor. HL403 has IC50 values of 133 nM for BRD4 inhibition and 4.5 nM for Src inhibition. HL403 shows anti-cancer activity[1].

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; Src

Type

Reference compound

Related Pathways

Epigenetics; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hl403.html

Solubility

10 mM in DMSO

Smiles

CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(N[C@@H](C)C(OCCN5CCN(CC5)C6=NC(C)=NC(NC7=NC=C(S7)C(NC8=C(C=CC=C8Cl)C)=O)=C6)=O)=O

Molecular Formula

C44H46Cl2N12O4S2

Molecular Weight

941.95

References & Citations

[1]Wang Y, et al. Design and synthesis of dual BRD4/Src inhibitors for treatment of triple-negative breast cancer. Eur J Med Chem. 2023 Nov 29;264:116009.