(S) -Phe-A110/B319
(S) -Phe-A110/B319 is a selective binde that has 20-fold higher affinity towards the H1047R mutant of p110α in the p110α/p85α PI3K complex[1].
Product Specifications
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/s-phe-a110-b319.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCC(N[C@H](CC(N[C@H](CCCCNC(NC(C=C1)=CC(C(O2)=O)=C1C32C4=C(OC5=CC(O)=CC=C53)C=C(C=C4)O)=S)C(O)=O)=O)C(O)=O)=O)[C@@H](NC(C6=CC=C7N=C(C(C)=NC7=C6)C)=O)CC8=CC=C(C=C8)C9=CC=C(C=C9C)OC(F)(F)F
Molecular Formula
C62H57F3N8O14S
Molecular Weight
1227.22
References & Citations
[1]Nicholas Favalli, et al. Stereo- and regiodefined DNA-encoded chemical libraries enable efficient tumour-targeting applications. Nat Chem. 2021 Jun;13 (6) :540-548.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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