ICI 89406

ICI 89406 is a selective β1 adrenergic receptor antagonist amenable to labelling with positron emitters, for PET[1][2].

Product Specifications

CAS Number

[53671-71-9]

UNSPSC

12352005

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ici-89406.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC=CC=C1)NCCNCC(O)COC2=CC=CC=C2C#N

Molecular Formula

C19H22N4O3

Molecular Weight

354.40

References & Citations

[1]Marilyn P Law, et al. Are [O-methyl-11C]derivatives of ICI 89,406 beta1-adrenoceptor selective radioligands suitable for PET? Eur J Nucl Med Mol Imaging. 2008 Jan;35 (1) :174-85.|[2]B Costall, et al. Changes in dopamine receptor status after denervation or chronic receptor stimulation [proceedings]. Br J Pharmacol. 1979 Jul;66 (3) :492P-493P.