Antitumor agent-125
Antitumor agent-125 (compound 17A) is a novel platinum (IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces ferroptosis in HCT-116/OXA[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Apoptosis; Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/antitumor-agent-125.html
Solubility
10 mM in DMSO
Smiles
Cl[Pt]12([NH2][C@@H]3CCCC[C@H]3[NH2]1)(OC(COC4=C(C=CC(C(/C=C/C(C(C)=N5)=NC(C)=C5C)=O)=C4)OC)=O)OC(C(O2)=O)=O
Molecular Formula
C27H33ClN4O9Pt
Molecular Weight
788.11
References & Citations
[1]Zhikun Liu, et al. Novel Platinum (IV) complexes intervene oxaliplatin resistance in colon cancer via inducing ferroptosis and apoptosis. Eur J Med Chem. 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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