Tolvaptan phosphate ester (sodium)

Tolvaptan phosphate ester sodium, a prodrug of Tolvaptan (HY-17000), can be used in the study of cardiac edema. Tolvaptan is a selective, competitive and orally active vasopressin receptor 2 (V2R) antagonist with an IC50 of 1.28 μM for the inhibition of arginine vasopressin (AVP) -induced platelet aggregation[1][2].

Product Specifications

CAS Number

[942619-79-6]

UNSPSC

12352005

Target

Vasopressin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tolvaptan-phosphate-ester-sodium.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 4.17 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)C=CC=C1)NC2=CC=C(C(C)=C2)C(N3C4=CC=C(C=C4C(CCC3)OP(O[Na])(O[Na])=O)Cl)=O

Molecular Formula

C26H24ClN2Na2O6P

Molecular Weight

572.88

References & Citations

[1]Hiroyuki Fujiki, et al. In vitro and in vivo pharmacological profile of OPC-61815, a water-soluble phosphate ester pro-drug of tolvaptan. J Pharmacol Sci. 2022 Nov;150 (3) :163-172.|[2]Wu Y, et al. Mechanisms of tolvaptan-induced toxicity in HepG2 cells. Biochem Pharmacol. 2015 Jun 15;95 (4) :324-36.