HDAC1 Degrader-1
HDAC1 Degrader-1 (compound 1a) is an HDAC1 degrader with anticancer activity. HDAC1 Degrader-1 significantly reduces HDAC1 levels in MM.1S multiple myeloma cells[1].
Product Specifications
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac1-degrader-1.html
Solubility
10 mM in DMSO
Smiles
O=C(NCCCCCCC(NO)=O)C1=CC=C(NC(CC2(C3)C[C@@H](C4)C[C@H]3C[C@@H]4C2)=O)C=C1
Molecular Formula
C26H37N3O4
Molecular Weight
455.59
References & Citations
[1]Feller F et al. Targeted Protein Degradation of Histone Deacetylases by Hydrophobically Tagged Inhibitors[J]. ACS Medicinal Chemistry Letters, 2023.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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